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KMID : 1035620220100020110
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Allergy Asthma & Respiratory Disease
2022 Volume.10 No. 2 p.110 ~ p.117
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Perilla seed allergy in children: Cosensitization and cross-reactivity with sesame seed
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Kim Hye-Bo
Gantulga Purevsan
Lee Eun-Joo
Lee Jeong-Min
Lee Soo-Young
Jeong Kyung-Uk
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Abstract
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Purpose: Perilla seed (PS) is the most common cause of seed-induced anaphylaxis in Korean children, but the reports on PS allergy, including phenotype and cross-reactivity, are rare. The aim of this study is to assess the clinical characteristics of PS allergy and investigate cross-reactivity with sesame seed (SS).
Methods: Through a retrospective medical record review, patients with clinical PS allergy were identified in a single tertiary hospital. Clinical characteristics of allergic reaction upon exposure to PS and SS, results of skin prick test (SPT) to PS and SS, and the levels of serum SS-specific immunoglobulin E (SS-sIgE) were investigated. Cross-reactivity between PS and SS was studied using IgE enzyme-linked immunosorbent assay (ELISA) inhibition.
Results: The median age of 34 PS-allergic children was 41.5 months (range, 10 months to 12 years), and the proportion of anaphylaxis upon exposure to PS was 29.4% (n=10). The PS SPT was positive in 94.1% (n=32) with the median wheal size of 6.25 mm. Among PS-allergic children, the percentages of patients with positive symptoms, negative symptoms, and indeterminate symptoms upon exposure to SS were 8.8%, 41.2%, and 50%, respectively. Out of 14 PS-allergic children who were tolerant to SS, positive sensitization to SS was noticed in 78.6% by serum SS-sIgE, and 57.1% by SS SPT. Partial cross-reactivity between PS and SS was identified in IgE ELISA inhibition.
Conclusion: This study reported the clinical profiles and SPT results in a relatively large number of PS-allergic children and identified the partial cross-reactivity between PS and SS for the first time.
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KEYWORD
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Cross reactions, Food hypersensitivity, Perilla frutescens, Seeds, Sesamum
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